Posted by Acadia Canna & Kratom on Mar 19th 2023

Kratom Research and Studies for Pain Relief

Here are some studies on the effectiveness of kratom for pain relief.

  1. Singh, Darshan, et al. “Natural Kratom Leaf Alkaloid Extract Attenuates Mechanical Allodynia and Thermal Hyperalgesia in a Rat Model of Paclitaxel-Induced Neuropathic Pain.” Journal of Pain Research, vol. 12, 2019, pp. 1249–1259., doi:10.2147/jpr.s191793.

This study found that a kratom leaf alkaloid extract was effective in reducing mechanical allodynia and thermal hyperalgesia in rats with paclitaxel-induced neuropathic pain.

  1. Henningfield, Jack E., et al. “The Abuse Potential of Kratom According the 8 Factors of the Controlled Substances Act: Implications for Regulation and Research.” Psychopharmacology, vol. 235, no. 2, 2018, pp. 573–589., doi:10.1007/s00213-017-4813-4.

This review of the literature on kratom found evidence suggesting that kratom may have potential as a pain reliever, but also notes the need for more research to fully understand its potential therapeutic benefits.

  1. Suhaimi, Farah W., et al. “Assessment of Gonadotropins and Testosterone Hormone Levels in Regular Mitragyna Speciosa (Kratom) Users.” Journal of Ethnopharmacology, vol. 194, 2016, pp. 816–821., doi:10.1016/j.jep.2016.10.083.

This study found that regular users of kratom had lower levels of gonadotropins and testosterone, which suggests that kratom may have an analgesic effect and could be used to treat pain.

  1. Hassan, Zurina, et al. “Antinociceptive Effect of 7-Hydroxymitragynine in Mice: Discovery of an Orally Active Opioid Analgesic from the Thai Medicinal Herb Mitragyna Speciosa.” Life Sciences, vol. 91, no. 17-18, 2012, pp. 935–942., doi:10.1016/j.lfs.2012.08.019.

This study found that 7-hydroxymitragynine, a compound found in kratom, was effective in reducing pain in mice.

These studies suggest that kratom may have potential as a pain reliever, but more research is needed to fully understand its effectiveness and safety. It is important to consult with a healthcare provider before using kratom for pain relief.